Differences

What is the difference between myeloblasts and lymphoblasts?

The main difference between myeloblasts and lymphoblasts is that myeloblasts differentiate into granulocytes, while lymphoblasts differentiate into lymphocytes. .. In addition, myeloblasts contain granules and lymphoblasts do not.

Myeloblasts and lymphoblasts are two types of progenitor cells that differentiate from blood cells during hematopoiesis. Here, hematopoietic blasts are pluripotent stem cells, which can differentiate into several types of progenitor cells.

Main areas to cover

What is Myeloblast
-Definition, Morphology, Pathology
What is Lymphoblast
-Definition, Morphology, Pathology
Similarities between Myeloblasts and Lymphoblasts
-Overview of Common Functions
What is the difference between myeloblasts and lymphoblasts?
–Comparison of major differences

Main terms

Acute lymphocytic leukemia (ALL), acute myeloblastic leukemia (AML), lymphoblasts, myeloblasts, nuclei

What are myeloblasts?

Try to understand:

myeloblasts

Myeloblasts are progenitor cells of granulocytes, neutrophils, eosinophils, and basophils. It is unipotent and distinct from pluripotent hematopoietic cells. In addition, the nucleus of myeloblasts can be S-type, C-type, or V-type. In addition, chromatin has a low density. Therefore, the nucleolus is more prominent. And the cytoplasm of myeloblasts contains granules.

Moreover, myeloblasts can be stained by myeloperoxidase staining. The presence of Auer rods is one of the key features of myeloblasts and helps identify them in bone marrow smears.

The development of granulocytes from myeloblasts is called granulopoiesis. Myeloblast dysfunction is acute myeloblast leukemia (AML) . It accumulates immature myelocytes in the peripheral blood and causes hematopoietic disorders. This leads to anemia, bleeding from the openings and recurrent infections.

What are lymphoblasts?

lymphoblasts

Lymphoblasts are progenitor cells of T and B lymphocytes. It is also distinguished from blood cell blast cells. The nucleus of lymphoblasts is round and contains compressed chromatin. Like myeloblasts, it does not contain prominent nucleoli and cytoplasmic granules.

Lymphocyte production is the process of differentiation from lymphoblasts to lymphocytes. Acute lymphocytic leukemia (all) is a condition in which overproduction of lymphoblasts occurs in the bone marrow . And it causes recurrent infections like pneumonia.

Similarities between myeloblasts and lymphoblasts

  • Myeloblasts and lymphoblasts are two types of progenitor cells that develop during hematopoiesis.
  • They are large and occur in the bone marrow.
  • Both also originate from hematopoietic blast cells.
  • In addition, both are monopoly cells.
  • In addition, their differentiation is triggered by cytokines.

Differences between myeloblasts and lymphoblasts

Definition

Myeloblasts refer to large bone marrow cells that act as precursors to myelocytes, and lymphocytes refer to other large bone marrow cells that act as precursors to lymphoblasts. Therefore, this is the main difference between myeloblasts and lymphoblasts.

Granules

Another difference between myeloblasts and lymphoblasts is that myeloblasts contain granules within the cytoplasm, whereas lymphoblasts do not.

Nuclear shape

In addition, the nucleus of myeloblasts is either S, C or V-shaped, while the nucleus of lymphoblasts is round.

Chromatin

Also, myeloblasts contain more concentrated chromatin, while lymphoblasts contain more concentrated chromatin.

Nucleoli

In addition, myeloblastic nuclei have prominent nucleoli, while lymphoblastic nuclei have less pronounced nucleoli.

diameter

The diameter of myeloblasts is 20 μm and the diameter of lymphoblasts is 15 μm.

Differentiate into

Myeloblasts can differentiate into basophils, eosinophils, and neutrophils, while lymphoblasts can differentiate into T and B lymphocytes. This is another important difference between myeloblasts and lymphoblasts.

Pathology

Myeloblasts dysfunction can cause acute myeloblastic leukemia (AML), while lymphoblast dysfunction can cause acute lymphoblastic leukemia (ALL).

Conclusion

Myeloblasts are progenitor cells of myelocytes. The three types of myelocytes are neutrophils, eosinophils, and basophils. Lymphocytes are progenitor cells of T and B lymphocytes. Both myeloblasts and lymphocytes are two types of monopoly cells that arise from blood cell blasts. The main difference between myeloblasts and lymphoblasts is the type of mature cells that result from them.

reference:

“Myeloblasts”, Encyclopedia Britannica, Encyclopedia Britannica, Inc. , July 20, 1998,

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